
Xtandi is co-owned by Pfizer Inc. (NYSE: PFE) and Astellas Pharma (Tokyo: 4503). Pfizer obtained its share through the September 2016 acquisition of Medivation for approximately $14 billion. Astellas holds rights in markets including Japan and shares global profits with Pfizer. Xtandi was first FDA approved in August 2012 for prostate cancer.
| Brand | Parent Company | Ownership Type |
|---|---|---|
| Xtandi | Pfizer Inc. | Licensed |
Enzalutamide was discovered at UCLA in the laboratory of Charles Sawyers and Michael Jung, whose work on androgen receptor biology identified the compound that Medivation licensed and developed. Medivation, led by CEO David Hung, partnered with Astellas in 2009: Astellas paid upfront and took development and commercialization rights outside the United States, while Medivation retained the US market.
The FDA approved Xtandi in August 2012 for post-chemotherapy metastatic castration-resistant prostate cancer, based on the AFFIRM trial showing improved survival. The indication expanded rapidly: pre-chemotherapy metastatic disease in 2014, non-metastatic castration-resistant prostate cancer in 2018, and metastatic castration-sensitive disease in 2019, each expansion widening the treatable population.
The drug became Medivation's crown jewel and the target of one of the more contested biotech acquisitions of the 2010s. Sanofi pursued a hostile bid for Medivation in 2016 before Pfizer prevailed with a $14 billion offer that closed in September 2016, a price driven substantially by Xtandi's sales trajectory and pipeline potential.
Under Pfizer, Xtandi generated billions annually as a flagship prostate cancer therapy, co-promoted with Astellas in the US. The collaboration's economics split global profits roughly evenly between the partners in the collaboration territories. Generic competition arrived in some markets and US patent litigation settlements established generic entry timelines, moderating the drug's forward revenue profile.
As of FY2025, Xtandi remains a significant contributor to Pfizer's oncology segment within the company's $62.6 billion total revenue, now joined by the Seagen-acquired oncology portfolio.
What does Pfizer own?
Pfizer owns a portfolio of prescription medicines and vaccines spanning oncology, cardiovascular, immunology, vaccines, and rare diseases. Key products include Eliquis (anticoagulant), Prevnar (pneumococcal vaccine), Ibrance (breast cancer), Vyndaqel (rare heart disease), Paxlovid (COVID-19 antiviral), Comirnaty (COVID-19 vaccine, with BioNTech), and Abrysvo (RSV vaccine). The 2023 acquisition of Seagen added oncology antibody-drug conjugates including Padcev, Adcetris, and Tukysa. The 2025 acquisition of Metsera added obesity treatment candidates to the pipeline.
Is Pfizer publicly traded?
Yes, Pfizer Inc. is listed on the New York Stock Exchange under ticker PFE. The company has been publicly traded since 1944. Pfizer has no single controlling shareholder, with major institutional holders including Vanguard Group, BlackRock, and State Street. Pfizer is a component of the Dow Jones Industrial Average and the S&P 500.
Who founded Pfizer?
Pfizer was founded in 1849 in Brooklyn, New York by Charles Pfizer and his cousin Charles Erhart. Charles Pfizer was a German-born chemist who emigrated to the United States. The company's first product was santonin, an antiparasitic agent. Pfizer's breakthrough into modern pharmaceuticals came during World War II when the company developed large-scale penicillin production using deep-tank fermentation.
Where is Pfizer headquartered?
Pfizer is headquartered in New York City, New York, USA. The company maintains its principal executive offices in Midtown Manhattan. Pfizer operates manufacturing facilities in the United States, Belgium, Ireland, the United Kingdom, Germany, Japan, China, India, and Brazil, and sells products in more than 125 countries worldwide.
How many products does Pfizer sell?
Pfizer sells dozens of prescription medicines and vaccines across multiple therapeutic areas. The company's portfolio includes products in oncology, vaccines, cardiovascular, immunology, rare diseases, and hospital products. Several of Pfizer's products each generate over $1 billion in annual revenue, including Eliquis, Prevnar, Ibrance, and Vyndaqel. The company's research pipeline includes hundreds of compounds in various stages of clinical development.
Who owns Pfizer?
Pfizer Inc. is publicly traded on the NYSE with a broad institutional and retail shareholder base. No single shareholder holds a controlling stake. Major institutional shareholders include Vanguard Group, BlackRock, and State Street. Albert Bourla serves as Chairman and CEO. Pfizer has no founding family or private equity controlling shareholder.
What is Pfizer's financial performance?
For full-year 2025, Pfizer reported revenue of $62.6 billion, a 2% decrease from $63.6 billion in FY2024. Excluding COVID-19 products (Comirnaty and Paxlovid), revenue grew 6% operationally. Net income was $7.77 billion, down 3% from $8.03 billion. Adjusted diluted EPS was $3.22, up 4% from $3.11. Net cash from operations was $11.7 billion. For FY2026, Pfizer projects revenue of $59.5 to $62.5 billion and adjusted diluted EPS of $2.80 to $3.00.
Xtandi's controversy record is limited to category-typical issues. Pricing criticism has targeted the drug's launch price and subsequent increases, with enzalutamide featured in congressional drug-pricing scrutiny and academic commentary on taxpayer-funded research commercialized at premium prices, since the compound originated in NIH-funded UCLA research.
Patent litigation between the partners and generic challengers has produced settlements establishing generic entry dates, a standard pharmaceutical process. Seizure risk and fatigue are labeled toxicities managed in prescribing. No market withdrawal or major safety recall has occurred.
These competing brands operate in the same categories and provide similar products or services. Compare key attributes to understand market positioning and competitive landscape.
| Brand | Parent Company | Country | Founded | Market Position | Primary Market | Gender Target |
|---|---|---|---|---|---|---|
| Bristol Myers Squibb | USA | 2014 | Mass market | Global | All Genders | |
| Pfizer | United States | 2011 | Mass market | North america | All Genders | |
| Pfizer | USA | 2015 | Mass market | Global | All Genders | |
| Pfizer | USA | 2019 | Mass market | Global | All Genders | |
| Pfizer | USA | 2020 | Mass market | Global | All Genders | |
| Novartis | Switzerland | 2009 | Mass market | North america | All Genders |
Healthcare PharmaceuticalsOwned by Bristol Myers Squibb Company
Opdivo (nivolumab) is Bristol Myers Squibb's flagship cancer immunotherapy, an anti-PD-1 antibody approved across more than a dozen tumor types.
Healthcare PharmaceuticalsOwned by Pfizer Inc.
Prescription antibody-drug conjugate treatment for classical Hodgkin lymphoma and CD30-expressing peripheral T-cell lymphomas, co-developed by Seagen and licensed to Takeda Pharmaceutical.
Healthcare PharmaceuticalsOwned by Pfizer Inc.
Pfizer's CDK4/6 inhibitor (palbociclib) for HR-positive, HER2-negative metastatic breast cancer, one of the company's largest oncology products since its 2015 approval.
Healthcare PharmaceuticalsOwned by Pfizer Inc.
Antibody-drug conjugate (enfortumab vedotin) for urothelial bladder cancer, co-developed by Seagen and Astellas and now owned by Pfizer through the 2023 Seagen acquisition.
Healthcare PharmaceuticalsOwned by Pfizer Inc.
Oral HER2 inhibitor (tucatinib) for HER2-positive breast cancer including brain metastases, acquired by Pfizer through the 2023 Seagen acquisition.
Healthcare PharmaceuticalsOwned by Novartis
Prescription oncology medicine (everolimus) used to treat certain cancers and tuberous sclerosis complex, developed and marketed by Novartis AG.
Market Positioning: Xtandi competes with 6 brands in the same categories, ranging from mass market to luxury positioning.
Geographic Distribution: Competitors are headquartered across multiple regions, indicating global competition in this market segment.
Brand Heritage: Competitor brands range from established heritage brands to newer market entrants, with founding years spanning several decades.
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Healthcare PharmaceuticalsOwned by Walgreens Boots Alliance
Boots is the UK's leading pharmacy-led health and beauty retailer, founded in 1849, now operating as The Boots Group under Sycamore Partners since August 2025.
Boots is privately owned, unlike Xtandi which is under a publicly traded parent company.
Healthcare PharmaceuticalsOwned by Walgreens Boots Alliance
Duane Reade is a New York City drugstore chain owned by Walgreen Co. under Sycamore Partners, operating approximately 90 stores across the five boroughs.
Duane Reade is privately owned, unlike Xtandi which is under a publicly traded parent company.
Healthcare PharmaceuticalsOwned by Chempro Chemists
Australian online pharmacy operated by Chempro Chemists from Molendinar, Queensland. Offers prescription medications, health products, and wellness items through digital platforms and mail-order delivery.
Pharmacy Direct is privately owned, unlike Xtandi which is under a publicly traded parent company.
Healthcare PharmaceuticalsOwned by EKR Therapeutics, Inc.
Retavase (reteplase) is a prescription thrombolytic medication indicated for acute ST-elevation myocardial infarction. Administered as two 10-unit intravenous bolus injections 30 minutes apart. Currently marketed by Chiesi USA.
Retavase is privately owned, unlike Xtandi which is under a publicly traded parent company.
Healthcare PharmaceuticalsOwned by IBSA Institut Biochimique S.A.
IBSA Institut Biochimique SA's branded levothyroxine softgel capsule (Tirosint) and liquid solution (Tirosint-SOL), FDA approved for hypothyroidism, formulated without dyes, gluten, lactose, alcohol, or sugar, providing an excipient-free alternative to conventional levothyroxine tablets for patients with sensitivities or absorption issues.
Tirosint is privately owned, unlike Xtandi which is under a publicly traded parent company.
Healthcare PharmaceuticalsOwned by Walgreens Boots Alliance
Walgreens is the largest U.S. pharmacy retail brand, operating roughly 8,000 stores. It went private in August 2025 under Sycamore Partners as a standalone company.
Walgreens is privately owned, unlike Xtandi which is under a publicly traded parent company.
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