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  1. Home
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  3. Healthcare & Pharmaceuticals
  4. Xtandi
Xtandi logo
Healthcare & Pharmaceuticals

Who Owns Xtandi?

Xtandi is co-owned by Pfizer Inc. (NYSE: PFE) and Astellas Pharma (Tokyo: 4503). Pfizer obtained its share through the September 2016 acquisition of Medivation for approximately $14 billion. Astellas holds rights in markets including Japan and shares global profits with Pfizer. Xtandi was first FDA approved in August 2012 for prostate cancer.

Parent Company

Pfizer Inc.

Acquired

2016

Status

Publicly Traded

Headquarters

New York, New York, USA

Xtandi Timeline

1849
Pfizer Inc.

Parent company established in New York, New York, USA

Company Founded
2012

Xtandi

Founded by Medivation Inc. (original commercialization), Astellas Pharma (co-developer)

Founded
2016
Acquired by Pfizer Inc.

Pfizer Inc. acquired Xtandi

Acquired
GlobalOfficial Website

Who Owns Xtandi?

  • Parent Company: Pfizer Inc.
  • Ownership Type: Licensed
  • Acquisition Year: 2016
  • Company Type: Publicly Traded
  • Stock Ticker: NYSE: PFE
BrandParent CompanyOwnership Type
XtandiPfizer Inc.Licensed

Where to Buy

Disclosure: We may earn commission from purchases
AmazonXtandi on Amazon

History of Xtandi

  • Founded: 2012
  • Founders: Medivation Inc. (original commercialization), Astellas Pharma (co-developer)
  • Acquired by Pfizer Inc.: 2016

Enzalutamide was discovered at UCLA in the laboratory of Charles Sawyers and Michael Jung, whose work on androgen receptor biology identified the compound that Medivation licensed and developed. Medivation, led by CEO David Hung, partnered with Astellas in 2009: Astellas paid upfront and took development and commercialization rights outside the United States, while Medivation retained the US market.

The FDA approved Xtandi in August 2012 for post-chemotherapy metastatic castration-resistant prostate cancer, based on the AFFIRM trial showing improved survival. The indication expanded rapidly: pre-chemotherapy metastatic disease in 2014, non-metastatic castration-resistant prostate cancer in 2018, and metastatic castration-sensitive disease in 2019, each expansion widening the treatable population.

The drug became Medivation's crown jewel and the target of one of the more contested biotech acquisitions of the 2010s. Sanofi pursued a hostile bid for Medivation in 2016 before Pfizer prevailed with a $14 billion offer that closed in September 2016, a price driven substantially by Xtandi's sales trajectory and pipeline potential.

Under Pfizer, Xtandi generated billions annually as a flagship prostate cancer therapy, co-promoted with Astellas in the US. The collaboration's economics split global profits roughly evenly between the partners in the collaboration territories. Generic competition arrived in some markets and US patent litigation settlements established generic entry timelines, moderating the drug's forward revenue profile.

As of FY2025, Xtandi remains a significant contributor to Pfizer's oncology segment within the company's $62.6 billion total revenue, now joined by the Seagen-acquired oncology portfolio.

About Pfizer Inc.

What does Pfizer own?
Pfizer owns a portfolio of prescription medicines and vaccines spanning oncology, cardiovascular, immunology, vaccines, and rare diseases. Key products include Eliquis (anticoagulant), Prevnar (pneumococcal vaccine), Ibrance (breast cancer), Vyndaqel (rare heart disease), Paxlovid (COVID-19 antiviral), Comirnaty (COVID-19 vaccine, with BioNTech), and Abrysvo (RSV vaccine). The 2023 acquisition of Seagen added oncology antibody-drug conjugates including Padcev, Adcetris, and Tukysa. The 2025 acquisition of Metsera added obesity treatment candidates to the pipeline.

Is Pfizer publicly traded?
Yes, Pfizer Inc. is listed on the New York Stock Exchange under ticker PFE. The company has been publicly traded since 1944. Pfizer has no single controlling shareholder, with major institutional holders including Vanguard Group, BlackRock, and State Street. Pfizer is a component of the Dow Jones Industrial Average and the S&P 500.

Who founded Pfizer?
Pfizer was founded in 1849 in Brooklyn, New York by Charles Pfizer and his cousin Charles Erhart. Charles Pfizer was a German-born chemist who emigrated to the United States. The company's first product was santonin, an antiparasitic agent. Pfizer's breakthrough into modern pharmaceuticals came during World War II when the company developed large-scale penicillin production using deep-tank fermentation.

Where is Pfizer headquartered?
Pfizer is headquartered in New York City, New York, USA. The company maintains its principal executive offices in Midtown Manhattan. Pfizer operates manufacturing facilities in the United States, Belgium, Ireland, the United Kingdom, Germany, Japan, China, India, and Brazil, and sells products in more than 125 countries worldwide.

How many products does Pfizer sell?
Pfizer sells dozens of prescription medicines and vaccines across multiple therapeutic areas. The company's portfolio includes products in oncology, vaccines, cardiovascular, immunology, rare diseases, and hospital products. Several of Pfizer's products each generate over $1 billion in annual revenue, including Eliquis, Prevnar, Ibrance, and Vyndaqel. The company's research pipeline includes hundreds of compounds in various stages of clinical development.

Who owns Pfizer?
Pfizer Inc. is publicly traded on the NYSE with a broad institutional and retail shareholder base. No single shareholder holds a controlling stake. Major institutional shareholders include Vanguard Group, BlackRock, and State Street. Albert Bourla serves as Chairman and CEO. Pfizer has no founding family or private equity controlling shareholder.

What is Pfizer's financial performance?
For full-year 2025, Pfizer reported revenue of $62.6 billion, a 2% decrease from $63.6 billion in FY2024. Excluding COVID-19 products (Comirnaty and Paxlovid), revenue grew 6% operationally. Net income was $7.77 billion, down 3% from $8.03 billion. Adjusted diluted EPS was $3.22, up 4% from $3.11. Net cash from operations was $11.7 billion. For FY2026, Pfizer projects revenue of $59.5 to $62.5 billion and adjusted diluted EPS of $2.80 to $3.00.

  • Founded: 1849
  • Headquarters: New York, New York, USA
  • Company Type: Publicly Traded
  • Stock: NYSE: PFE
  • Revenue: $62.6 billion (FY2025)
  • Employees: approximately 88,000

Visit Pfizer Inc. website

View full company profile for Pfizer Inc.

Where Is Xtandi Made / Based?

  • Headquarters: New York, New York, USA
  • Manufacturing / Operations: United States, Japan, Ireland

Xtandi Categories & Tags

OncologyProstate CancerAndrogen InhibitorPrescription DrugCancer Treatment

Xtandi Recalls & Controversies

Xtandi's controversy record is limited to category-typical issues. Pricing criticism has targeted the drug's launch price and subsequent increases, with enzalutamide featured in congressional drug-pricing scrutiny and academic commentary on taxpayer-funded research commercialized at premium prices, since the compound originated in NIH-funded UCLA research.

Patent litigation between the partners and generic challengers has produced settlements establishing generic entry dates, a standard pharmaceutical process. Seizure risk and fatigue are labeled toxicities managed in prescribing. No market withdrawal or major safety recall has occurred.

Brands Owned by Pfizer Inc.

AbrysvoHealthcare Pharmaceuticals

Abrysvo

Owned by Pfizer Inc.

Pfizer's respiratory syncytial virus (RSV) vaccine approved for older adults, maternal immunization to protect infants, and younger at-risk adults. Launched 2023.

rsv-vaccinevaccinesmaternal-immunization
AdcetrisHealthcare Pharmaceuticals

Adcetris

Owned by Pfizer Inc.

Prescription antibody-drug conjugate treatment for classical Hodgkin lymphoma and CD30-expressing peripheral T-cell lymphomas, co-developed by Seagen and licensed to Takeda Pharmaceutical.

oncologyantibody-drug-conjugatelymphoma
CaduetHealthcare Pharmaceuticals

Caduet

Owned by Pfizer Inc.

Prescription combination drug containing amlodipine and atorvastatin, co-promoted by Pfizer and developed for simultaneous blood pressure and cholesterol management.

prescription-drugcardiovascularhypertension
CelebrexHealthcare Pharmaceuticals

Celebrex

Owned by Pfizer Inc.

Prescription COX-2 inhibitor anti-inflammatory medication for treating arthritis pain, originally developed by G.D. Searle & Company and now marketed by Pfizer.

pain-reliefanti-inflammatoryarthritis
ChantixHealthcare Pharmaceuticals

Chantix

Owned by Pfizer Inc.

Prescription smoking cessation medication (varenicline) developed by Pfizer, FDA-approved in 2006.

smoking-cessationvareniclinenicotinic-receptor
ComirnatyHealthcare Pharmaceuticals

Comirnaty

Owned by Pfizer Inc.

Pfizer-BioNTech COVID-19 mRNA vaccine, the first FDA-approved COVID vaccine in the United States, co-commercialized globally by Pfizer and BioNTech.

covid-19mrna-vaccinevaccines
View all brands owned by Pfizer Inc.

Xtandi Ownership: Pros & Cons

Advantages

  • +Market-leading androgen inhibitor with successive label expansions across disease stages
  • +Pfizer-Astellas split provides both partners global commercial infrastructure
  • +Medivation acquisition delivered an established blockbuster rather than pipeline risk
  • +Deep urologist and oncologist familiarity after more than a decade on market

Considerations

  • -Profit split with Astellas limits Pfizer's margin retention on shared territory sales
  • -Generic competition timelines are set through patent settlements, capping long-term growth
  • -Bayer's Nubeqa has gained share in overlapping indications
  • -Pricing scrutiny on a drug originating in publicly funded academic research is persistent

Frequently Asked Questions About Xtandi

Sources & Further Reading

  • Xtandi Product Website
  • Pfizer Investor Relations
  • Astellas Pharma
  • SEC EDGAR: Pfizer Filings
  • Wikidata: Enzalutamide

Competitors to Xtandi

These competing brands operate in the same categories and provide similar products or services. Compare key attributes to understand market positioning and competitive landscape.

BrandParent CompanyCountryFoundedMarket PositionPrimary MarketGender Target
OpdivoOpdivo
Bristol Myers Squibb
USA
2014
Mass marketGlobalAll Genders
AdcetrisAdcetrisSister Brand
Pfizer
United States
2011
Mass marketNorth americaAll Genders
IbranceIbranceSister Brand
Pfizer
USA
2015
Mass marketGlobalAll Genders
PadcevPadcevSister Brand
Pfizer
USA
2019
Mass marketGlobalAll Genders
TukysaTukysaSister Brand
Pfizer
USA
2020
Mass marketGlobalAll Genders
AfinitorAfinitor
Novartis
Switzerland
2009
Mass marketNorth americaAll Genders

Learn More About Competitors

OpdivoHealthcare Pharmaceuticals

Opdivo

Owned by Bristol Myers Squibb Company

Opdivo (nivolumab) is Bristol Myers Squibb's flagship cancer immunotherapy, an anti-PD-1 antibody approved across more than a dozen tumor types.

prescription-drugoncologyimmunotherapy
AdcetrisHealthcare Pharmaceuticals

Adcetris

Owned by Pfizer Inc.

Prescription antibody-drug conjugate treatment for classical Hodgkin lymphoma and CD30-expressing peripheral T-cell lymphomas, co-developed by Seagen and licensed to Takeda Pharmaceutical.

oncologyantibody-drug-conjugatelymphoma
IbranceHealthcare Pharmaceuticals

Ibrance

Owned by Pfizer Inc.

Pfizer's CDK4/6 inhibitor (palbociclib) for HR-positive, HER2-negative metastatic breast cancer, one of the company's largest oncology products since its 2015 approval.

oncologybreast-cancercdk46-inhibitor
PadcevHealthcare Pharmaceuticals

Padcev

Owned by Pfizer Inc.

Antibody-drug conjugate (enfortumab vedotin) for urothelial bladder cancer, co-developed by Seagen and Astellas and now owned by Pfizer through the 2023 Seagen acquisition.

oncologybladder-cancerantibody-drug-conjugate
TukysaHealthcare Pharmaceuticals

Tukysa

Owned by Pfizer Inc.

Oral HER2 inhibitor (tucatinib) for HER2-positive breast cancer including brain metastases, acquired by Pfizer through the 2023 Seagen acquisition.

oncologybreast-cancerher2
AfinitorHealthcare Pharmaceuticals

Afinitor

Owned by Novartis

Prescription oncology medicine (everolimus) used to treat certain cancers and tuberous sclerosis complex, developed and marketed by Novartis AG.

oncologycancerpharmaceutical

Competitive Analysis

Market Positioning: Xtandi competes with 6 brands in the same categories, ranging from mass market to luxury positioning.

Geographic Distribution: Competitors are headquartered across multiple regions, indicating global competition in this market segment.

Brand Heritage: Competitor brands range from established heritage brands to newer market entrants, with founding years spanning several decades.

Independent Alternatives to Xtandi

Looking for brands with different ownership structures? These similar brands are not owned by Pfizer Inc., giving you alternative choices that support different corporate structures.

BootsHealthcare Pharmaceuticals

Boots

Owned by Walgreens Boots Alliance

Boots is the UK's leading pharmacy-led health and beauty retailer, founded in 1849, now operating as The Boots Group under Sycamore Partners since August 2025.

pharmacyhealth-beautyuk-retail
Privately Owned

Boots is privately owned, unlike Xtandi which is under a publicly traded parent company.

Duane ReadeHealthcare Pharmaceuticals

Duane Reade

Owned by Walgreens Boots Alliance

Duane Reade is a New York City drugstore chain owned by Walgreen Co. under Sycamore Partners, operating approximately 90 stores across the five boroughs.

pharmacydrugstorenew-york
Privately Owned

Duane Reade is privately owned, unlike Xtandi which is under a publicly traded parent company.

Pharmacy DirectHealthcare Pharmaceuticals

Pharmacy Direct

Owned by Chempro Chemists

Australian online pharmacy operated by Chempro Chemists from Molendinar, Queensland. Offers prescription medications, health products, and wellness items through digital platforms and mail-order delivery.

online-pharmacymail-orderdigital-health
Privately Owned

Pharmacy Direct is privately owned, unlike Xtandi which is under a publicly traded parent company.

RetavaseHealthcare Pharmaceuticals

Retavase

Owned by EKR Therapeutics, Inc.

Retavase (reteplase) is a prescription thrombolytic medication indicated for acute ST-elevation myocardial infarction. Administered as two 10-unit intravenous bolus injections 30 minutes apart. Currently marketed by Chiesi USA.

pharmaceuticalthrombolyticreteplase
Privately Owned

Retavase is privately owned, unlike Xtandi which is under a publicly traded parent company.

TirosintHealthcare Pharmaceuticals

Tirosint

Owned by IBSA Institut Biochimique S.A.

IBSA Institut Biochimique SA's branded levothyroxine softgel capsule (Tirosint) and liquid solution (Tirosint-SOL), FDA approved for hypothyroidism, formulated without dyes, gluten, lactose, alcohol, or sugar, providing an excipient-free alternative to conventional levothyroxine tablets for patients with sensitivities or absorption issues.

levothyroxinehypothyroidismthyroid
Privately Owned

Tirosint is privately owned, unlike Xtandi which is under a publicly traded parent company.

WalgreensHealthcare Pharmaceuticals

Walgreens

Owned by Walgreens Boots Alliance

Walgreens is the largest U.S. pharmacy retail brand, operating roughly 8,000 stores. It went private in August 2025 under Sycamore Partners as a standalone company.

pharmacydrugstoreretail-pharmacy
Privately Owned

Walgreens is privately owned, unlike Xtandi which is under a publicly traded parent company.

Pfizer Inc. Stock Information

Jobs at Pfizer Inc.

Latest News About Xtandi

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Last reviewed: September 25, 2026 · Reviewed by Who Brands Editorial Team