Healthcare PharmaceuticalsLeucovorin
Owned by Pfizer
Generic prescription folinic acid (5-formyltetrahydrofolate) used for methotrexate rescue in high-dose methotrexate chemotherapy, as a biochemical modulator of fluorouracil (5-FU) in colorectal cancer regimens including FOLFOX and FOLFIRI, and for treatment of megaloblastic anemia; originally developed by Lederle Laboratories in the 1940s and now manufactured by multiple pharmaceutical companies including Pfizer/Hospira, Teva, and Fresenius Kabi.
folinic-acidmethotrexate-rescuecolorectal-cancer