
Eliquis (apixaban) is co-owned by Bristol-Myers Squibb (NYSE: BMY) and Pfizer (NYSE: PFE) under a worldwide collaboration agreement signed in 2007. BMS discovered the drug and the two companies share development costs and profits equally on a global basis. Eliquis generated $14.4 billion in worldwide revenue in 2025, making it one of the best-selling pharmaceutical products of all time. US generic entry is set for April 2028 under patent litigation settlements.
| Brand | Parent Company | Ownership Type |
|---|---|---|
| Eliquis | Pfizer Inc. | Co owned |
Apixaban was discovered by researchers at Bristol-Myers Squibb. The compound is a small molecule that selectively inhibits factor Xa, an enzyme in the coagulation cascade that plays a central role in blood clot formation. By blocking factor Xa, apixaban reduces the production of thrombin, the enzyme that converts fibrinogen to fibrin, thereby preventing clot formation.
BMS and Pfizer announced their worldwide collaboration on apixaban on April 26, 2007. The agreement covered development and commercialization across a broad range of venous and arterial thrombotic conditions. At the time, apixaban was in Phase III clinical trials. The European Medicines Agency approved Eliquis in May 2011 for prevention of venous thromboembolism after elective hip or knee replacement surgery. The FDA approved Eliquis on December 28, 2012, for reducing the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation.
Subsequent FDA approvals expanded Eliquis's indications. In 2014, the FDA approved Eliquis for the prophylaxis of deep vein thrombosis and pulmonary embolism in patients who have undergone hip or knee replacement surgery. Later that year, the agency approved Eliquis for the treatment of DVT and PE, and for reducing the risk of recurrence of DVT and PE following initial therapy.
The ARISTOTLE trial, published in the New England Journal of Medicine in 2011, was the pivotal study that demonstrated Eliquis's superiority over warfarin. The trial enrolled over 18,000 patients with atrial fibrillation and showed that apixaban reduced the risk of stroke or systemic embolism by 21 percent compared to warfarin, while also causing significantly less major bleeding and lowering overall mortality. These results established Eliquis as a preferred oral anticoagulant and drove rapid adoption.
By the mid-2010s, Eliquis had become the market-leading oral anticoagulant in the United States and globally. Sales grew from approximately $774 million in 2015 to over $10 billion by 2022. In 2025, worldwide Eliquis revenue reached $14.4 billion, with BMS reporting $10.2 billion in U.S. sales and $4.2 billion internationally, and Pfizer reporting approximately $7.96 billion in combined alliance and product revenues.
In 2026, Eliquis continued to grow despite the implementation of Medicare price negotiation under the Inflation Reduction Act. A Medicare maximum fair price of $231 per 30-day supply took effect on January 1, 2026. BMS and Pfizer also began selling Eliquis directly to cash-paying U.S. patients at a discount of more than 40 percent, and reduced the list price for commercial patients. In the second quarter of 2026, BMS reported Eliquis sales of $4.48 billion, up 22 percent year over year, driven by growth in demand. BMS raised its full-year 2026 Eliquis revenue growth guidance to 20 to 25 percent, up from its previous forecast of 10 to 15 percent.
What does Pfizer own?
Pfizer owns a portfolio of prescription medicines and vaccines spanning oncology, cardiovascular, immunology, vaccines, and rare diseases. Key products include Eliquis (anticoagulant), Prevnar (pneumococcal vaccine), Ibrance (breast cancer), Vyndaqel (rare heart disease), Paxlovid (COVID-19 antiviral), Comirnaty (COVID-19 vaccine, with BioNTech), and Abrysvo (RSV vaccine). The 2023 acquisition of Seagen added oncology antibody-drug conjugates including Padcev, Adcetris, and Tukysa. The 2025 acquisition of Metsera added obesity treatment candidates to the pipeline.
Is Pfizer publicly traded?
Yes, Pfizer Inc. is listed on the New York Stock Exchange under ticker PFE. The company has been publicly traded since 1944. Pfizer has no single controlling shareholder, with major institutional holders including Vanguard Group, BlackRock, and State Street. Pfizer is a component of the Dow Jones Industrial Average and the S&P 500.
Who founded Pfizer?
Pfizer was founded in 1849 in Brooklyn, New York by Charles Pfizer and his cousin Charles Erhart. Charles Pfizer was a German-born chemist who emigrated to the United States. The company's first product was santonin, an antiparasitic agent. Pfizer's breakthrough into modern pharmaceuticals came during World War II when the company developed large-scale penicillin production using deep-tank fermentation.
Where is Pfizer headquartered?
Pfizer is headquartered in New York City, New York, USA. The company maintains its principal executive offices in Midtown Manhattan. Pfizer operates manufacturing facilities in the United States, Belgium, Ireland, the United Kingdom, Germany, Japan, China, India, and Brazil, and sells products in more than 125 countries worldwide.
How many products does Pfizer sell?
Pfizer sells dozens of prescription medicines and vaccines across multiple therapeutic areas. The company's portfolio includes products in oncology, vaccines, cardiovascular, immunology, rare diseases, and hospital products. Several of Pfizer's products each generate over $1 billion in annual revenue, including Eliquis, Prevnar, Ibrance, and Vyndaqel. The company's research pipeline includes hundreds of compounds in various stages of clinical development.
Who owns Pfizer?
Pfizer Inc. is publicly traded on the NYSE with a broad institutional and retail shareholder base. No single shareholder holds a controlling stake. Major institutional shareholders include Vanguard Group, BlackRock, and State Street. Albert Bourla serves as Chairman and CEO. Pfizer has no founding family or private equity controlling shareholder.
What is Pfizer's financial performance?
For full-year 2025, Pfizer reported revenue of $62.6 billion, a 2% decrease from $63.6 billion in FY2024. Excluding COVID-19 products (Comirnaty and Paxlovid), revenue grew 6% operationally. Net income was $7.77 billion, down 3% from $8.03 billion. Adjusted diluted EPS was $3.22, up 4% from $3.11. Net cash from operations was $11.7 billion. For FY2026, Pfizer projects revenue of $59.5 to $62.5 billion and adjusted diluted EPS of $2.80 to $3.00.
Eliquis has maintained a strong safety profile since its FDA approval in 2012, but the drug has been the subject of several notable controversies and legal proceedings.
Patent Litigation: BMS and Pfizer have actively enforced the Eliquis patent estate through Hatch-Waxman litigation against multiple generic manufacturers seeking to market apixaban in the United States. In September 2024, the companies sued Indian generic manufacturer Umedica Laboratories in the District of Delaware over patent US9326945B2. The case was voluntarily dismissed without prejudice after 15 days. Settlements with other generic manufacturers established the April 2028 U.S. generic entry date.
Medicare Price Negotiation: Eliquis was among the first 10 drugs selected for Medicare price negotiation under the Inflation Reduction Act. The negotiated maximum fair price of $231 per 30-day supply took effect on January 1, 2026. BMS and Pfizer have criticized the negotiation process, arguing that the reduced price could impact revenue ahead of the 2028 patent cliff. However, BMS raised its 2026 Eliquis revenue guidance after stronger-than-expected demand in the first half of the year.
Bleeding Risk: Like all anticoagulants, Eliquis carries a risk of bleeding, including life-threatening hemorrhage. The drug carries an FDA boxed warning advising against premature discontinuation and noting that spinal and epidural hematomas can occur in patients receiving neuraxial anesthesia. These risks are well-characterized and reflected in the prescribing information.
Pricing and Access: Eliquis has faced criticism over its high cost, particularly in the United States where the list price has been significantly higher than in other countries. The Medicare price negotiation and the companies' voluntary cash-price discount program represent responses to these concerns.
These competing brands operate in the same categories and provide similar products or services. Compare key attributes to understand market positioning and competitive landscape.
| Brand | Parent Company | Country | Founded | Market Position | Primary Market | Gender Target |
|---|---|---|---|---|---|---|
| Sanofi | France | 1993 | Mass market | Global | All Genders |
Market Positioning: Eliquis competes with 1 brands in the same categories, ranging from mass market to luxury positioning.
Geographic Distribution: Competitors are headquartered across multiple regions, indicating global competition in this market segment.
Brand Heritage: Competitor brands range from established heritage brands to newer market entrants, with founding years spanning several decades.
Looking for brands with different ownership structures? These similar brands are not owned by Pfizer Inc., giving you alternative choices that support different corporate structures.
Healthcare PharmaceuticalsOwned by Chempro Chemists
Australian online pharmacy operated by Chempro Chemists from Molendinar, Queensland. Offers prescription medications, health products, and wellness items through digital platforms and mail-order delivery.
Pharmacy Direct is privately owned, unlike Eliquis which is under a publicly traded parent company.
Healthcare PharmaceuticalsOwned by IBSA Institut Biochimique S.A.
IBSA Institut Biochimique SA's branded levothyroxine softgel capsule (Tirosint) and liquid solution (Tirosint-SOL), FDA approved for hypothyroidism, formulated without dyes, gluten, lactose, alcohol, or sugar, providing an excipient-free alternative to conventional levothyroxine tablets for patients with sensitivities or absorption issues.
Tirosint is privately owned, unlike Eliquis which is under a publicly traded parent company.
Healthcare PharmaceuticalsOwned by Novo Nordisk
Danish pharmaceutical company specializing in diabetes care and obesity treatment. Founded in 1923, headquartered in Bagsvaerd, Denmark. World leader in diabetes care and a leader in obesity treatment with Ozempic, Wegovy, and the investigational CagriSema. CEO Lars Fruergaard Jorgensen departed in March 2025; interim leadership under board chairman Helge Lund until a permanent CEO is appointed.
Novo Nordisk operates independently without a large parent corporation.
Healthcare PharmaceuticalsOwned by Alcon Inc.
Independent publicly traded global eye care company headquartered in Geneva, Switzerland, specializing in surgical equipment, contact lenses, and ophthalmic products. Spun off from Novartis in April 2019.
Alcon operates independently without a large parent corporation.
Healthcare PharmaceuticalsOwned by GE HealthCare Technologies Inc.
Independent publicly traded healthcare technology company spun off from General Electric in January 2023, providing medical imaging, diagnostics, and healthcare IT solutions globally.
GE HealthCare operates independently without a large parent corporation.
Healthcare PharmaceuticalsOwned by GoodRx Holdings, Inc.
American healthcare technology platform providing prescription drug price comparison, discount coupons, and telehealth services to help consumers find affordable healthcare options.
GoodRx operates independently without a large parent corporation.
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